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pentobarbital will reduce the level or influence of clozapine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital will lower the level or impact of guanfacine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Strong or reasonable CYP3A4 inducers drastically lessen g